Which smoking cessation medication is contraindicated in patients with a history of seizures?

The correct choice highlights Bupropion as the smoking cessation medication contraindicated in patients with a history of seizures. This is primarily due to the medication's mechanism of action as a norepinephrine-dopamine reuptake inhibitor, which can lower the seizure threshold in susceptible individuals.

In patients with a history of seizure disorders, using Bupropion can increase the risk of seizures occurring, which is a significant safety concern. Therefore, healthcare providers typically avoid prescribing this medication to these patients.

In contrast, Varenicline, nicotinic gum, and nicotine replacement therapy (NRT) patches generally do not have the same contraindication related to seizure history. Varenicline specifically may have other considerations, but the risk related to seizures is not as pronounced as it is with Bupropion. Nicotine gum and NRT patches work by providing nicotine replacement without affecting seizure thresholds, making them safer alternatives for individuals with seizure disorders.