Which nicotine replacement therapy (NRT) strategy has the best efficacy?

The most effective nicotine replacement therapy strategy involves using a combination of long-acting and short-acting therapies. This approach maximizes the benefits of nicotine replacement by addressing cravings and withdrawal symptoms more effectively throughout the day. Long-acting therapies, such as nicotine patches, provide a steady level of nicotine to help reduce overall withdrawal symptoms and cravings, but they may not be sufficient for sudden cravings that occur in certain situations.

In contrast, short-acting therapies, like nicotine gum or lozenges, can be used on demand to provide quick relief from acute cravings. This combination allows individuals to maintain a baseline level of nicotine while having the flexibility to manage sudden urges effectively. Studies demonstrate that using both long-acting and short-acting forms of NRT significantly increases the chances of successful smoking cessation compared to using either type alone, which is why the combination strategy is recognized as the most efficacious.

This synergistic effect takes advantage of the benefits of both types of therapies, ultimately supporting individuals in their journey to quit smoking more successfully.